Preclinical applications and studies
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A Versatile Application For Rapid Mass Confirmation And Purity Assessment Of Biotherapeutics
7/18/2022
We explore a streamlined integrated workflow for data acquisition, processing and reporting of deconvoluted mass data for biotherapeutics, deployable in regulated and non-regulated environments.
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Transferring N-Glycan HILIC Separations Between UPLC And HPLC
7/18/2022
We demonstrate that comparable chromatographic profiles and relative quantitation can be achieved with the larger particle size column at HPLC-compatible pressures, albeit with an increase in sample load, mobile phase use, and most importantly, analysis time.
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Improving Released N-glycan Analysis In Biotherapeutic Development Using Premier Solution With HPS Technology
7/12/2022
Explore how we improved releasing N-glycan analysis in biotherapeutic development, which can help develop robust and unbiased glycan assays for biotherapeutic development, manufacture, and release.
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Method Migration Of Size-Exclusion And Ion- Exchange Methods For Monoclonal Antibody Analysis
7/12/2022
Discover how combining this system with modern UHPLC columns could make data more accurately interpreted through greater efficiency, selectivity, and enhanced resolution.
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Rapid Size Variant Analysis of Monoclonal Antibodies Using SEC Columns
7/9/2022
This study examines technological advancements in both the column hardware and packed particle chemistry of solution that provides extended column lifetimes when using physiological pH mobile phases.
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ACQUITY And XBridge Premier Protein SEC 250 Å Columns: A New Benchmark In Inert SEC Column Design
7/5/2022
We demonstrate the performance of a new column technology designed to provide a holistic solution to the problems of undesired secondary interactions in SEC.
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Performance Stability Of CORTECS 2.7 μm Columns Following Repeated Injections Of Precipitated Plasma
7/1/2022
We review a column made using optimally packed solid-core particles. These columns are designed to tolerate repeated injections of minimally processed samples, while maintaining assay performance.
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Improvements In Recovery, Reproducibility, And Matrix Effects With A Novel Solid Phase Extraction Sorbent
6/30/2022
In this study we review a successful next generation reversed solid-phase extraction (SPE) product that produces cleaner extracts with simpler protocols and faster processing time.
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Selecting A Reversed-Phase Column For The Peptide Mapping Analysis Of A Biotherapeutic Protein
6/30/2022
In this study we review reversed-phase (RP) column selection considerations for peptide mapping applied to the routine characterization and analysis of biotherapeutic proteins.
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BEH C18 Batch-To-Batch Robustness For The Analysis Of Rosuvastatin And Impurities
6/30/2022
The main goal of this study is to investigate the long-term batch-to-batch reproducibility of 10 different lots of XBridge BEH C18 Columns. Discover the findings of this study.