Adaptive Design In Clinical Trials: Advantages Of Outsourcing

By Russ Reeve, VP Biostatistics

The pharmaceutical industry faces growing pressure to reduce cost and accelerate timelines for new therapeutics while navigating regulatory changes, increasing competition and the continuing effects of a global pandemic. To accelerate therapeutic development and to de-risk studies, adaptive clinical trials are being used more frequently. This type of design allows researchers to anticipate and modify trial elements during conduct, while preserving scientific and statistical integrity. The advantages of adaptive designs, include:

• Potentially reduced timelines for the development
• Reduced risk of trial failure since the trial can adaptive to the trial reality instead of being anchored in the assumptions
• Resources can be allocated to the most promising therapeutics in the portfolio