Electronic data capture (EDC), which has provided a reliable and manageable alternative to paper for the storage of patient data, has begun to shift toward cloud services, significantly expanding researchers’ abilities to share and access clinical data. However, in something of an ironic twist, there are some areas within clinical research for which the internet - or, to be more precise, dependence upon it - serves as a barrier rather than a catalyst. A product of eSource technology, offline data entry allows researchers to capture data on a mobile application, such as a tablet, even in the absence of an internet connection. The data then automatically syncs with an EDC when connectivity is restored. What kinds of researchers stand to benefit the most from offline data entry, and how does it serve their needs?