Article | June 25, 2021

A Data-Infused Approach To De-Risking Clinical Trials

Source: Cytel
5 (Fairly Simple) Statistical Analysis Plan Elements To Implement In Your Clinical Study

For many decades the Pareto Frontier has been employed by actors in the private sector to evaluate and understand the benefits of various strategic options. When trying to understand the risks and benefits of a clinical strategy, Cytel researchers urge using a modified version of this process, built primarily with clinical development in mind. Their new position paper describes two functional uses of the Pareto concept for clinical trials - the selection of a de-risked trial design, and an improved understanding of the financial nature of the tradeoffs between various operational parameters of clinical trial design.

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