American Academy Of Ophthalmology IRIS Registry (Intelligent Research In Sight) Industry Report

The 2024 IRIS^® Registry Industry Report, developed in collaboration with Verana Health and the American Academy of Ophthalmology, showcases the transformative power of real-world data (RWD) in ophthalmology. Drawing from over 83 million de-identified patients and nearly 753 million billable visits, the IRIS Registry stands as the largest specialty clinical data registry in medicine.

The report highlights Verana Health’s AI-driven curation methods, including natural language processing (NLP) and machine learning, which convert unstructured electronic health record (EHR) data into research-ready Qdata^®. Newly expanded Qdata modules in 2024—for dry eye disease, thyroid eye disease, retinitis pigmentosa, and uveitic macular edema—enhance disease-specific insights and clinical research potential. The report also details the impact of these datasets on scientific discovery, with applications in regulatory reporting, real-world evidence (RWE) generation, and clinical trial optimization. Key studies demonstrate improved understanding of treatment outcomes in diabetic macular edema, geographic atrophy, and glaucoma.