Breaking Through Barriers With Integrated Trial Optimization

In today’s complex clinical trial environment, optimizing trial design requires a multidimensional strategy that balances scientific rigor with real-world constraints. PPD’s Integrated Trial Optimization (ITO) Solutions offer a data-driven, patient-centric framework for aligning stakeholder priorities—regulators, payers, sites, and patients—early in the trial design process. By integrating feasibility studies, operational insights, decentralized trial strategies, and patient input, ITO enables sponsors to make informed design trade-offs that enhance enrollment, retention, and overall trial efficiency. Tools such as StudyGage™ quantify patient burden, helping sponsors forecast participation impact and streamline operational planning. ITO supports accelerated clinical development while minimizing costly amendments. The COPD case study exemplifies the impact of PPD's ITO Service Team, achieving a 9% reduction in required sites and a 5% budget savings—proving that smarter design can yield faster timelines and stronger outcomes. With its flexible delivery process and integrated capabilities, ITO empowers sponsors to confidently shape trials that are scientifically sound, operationally feasible, and aligned with market access and regulatory success.