Changes In Research: What Are They And When Do They Need To Be Submitted To The IRB?

Changes in Research (CIRs) are one of the most common topics for inquiries that come to the Institutional Review Board (IRB). This post addresses two of the most frequent questions asked and general guidance around CIRs, discussing  what should be considered a CIR and where  there is flexibility in the processes and regulations to decrease the administrative  burdens but maintain compliance.