Newsletter | October 21, 2026

10.21.26 -- Choose Your Approach: Traditional, Hybrid Or Decentralized

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How to Avoid False Negatives in Early CNS Development

Promising CNS compounds may be stopped too early when pharmacological effects go undetected. Learn why false negatives occur in early clinical development and explore six practical strategies to improve signal detection, strengthen confidence in pharmacodynamic findings, and support more informed go/no-go decisions. Read the article.

DECENTRALIZED TRIALS

 

Where The FDA And EMA Stand On Digital Endpoints

In part two of this series on digital endpoints, consultant Anita Burrell reviews the extent of their regulatory acceptance and discusses how to ensure data produced from digital technologies satisfies regulators.

 

Traditional, Hybrid, Or Decentralized: What Actually Works?

Learn how traditional, decentralized, and community-based approaches address different study challenges and support more effective, patient-centered research.

TRIAL MANAGEMENT

 

From Feasibility To Reality: Will Your Trial Actually Enroll?

In this Clinical Leader Live, panelists Vanessa Gertsen, Kasia Harris, and Nick Palumbo examined whether traditional feasibility approaches are giving study teams the information they really need.

 

Delivering Value In Clinical Trial Services

Gain insights into managing the complexity of global trials, balancing accelerated timelines with compliance, using advanced technologies, and leveraging partnerships to ensure seamless operations.

 

Elevating IDS Practice Through Continuing Education

Discover how leading IDS teams are using automation and standardized digital workflows to streamline protocol management, reduce errors, improve efficiency, and strengthen research operations.

 

3 Components Of Successful Renal And Hepatic Impairment Studies

Kidney and liver function affect how drugs work in the body. Learn how impairment studies help set safe, effective dosing for these patients.

 

Unifying Research - Tribal Health And Research And Patient Michele

Kelsey Powell explores the urgent need for better clinical research access in tribal healthcare, while Michele Baptista shares how her cancer journey led to a research opportunity that changed her life.

 

Using Immune Challenges To Reveal Pharmacology Early

Controlled immune challenges can reveal target engagement and pharmacology before efficacy is measurable, supporting earlier and more informed development decisions.

 

The Answer To Advance Your Allogeneic CAR-T Cell Clinical Trial

Dozens of assays, a shifting sample analysis plan, and a network of specialty labs: see how coordinated oversight kept an allogeneic CAR-T trial on track.

 

From Data Delays To Decision Speed

The biggest risk in modern trials isn’t missing data. It’s delayed insight. Discover how real-time intelligence helps teams act faster, reduce risk, and improve trial execution.

 

Flexible Supply Strategies For Complex Clinical Trials

Explore how demand-led, decentralized clinical supply models are reshaping complex trials by reducing waste, accelerating timelines, and advancing patient-centric access to investigational therapies.

 

Cardiovascular, Renal, And Metabolic Clinical Development

CVRM trials must address comorbidities and complex needs. See how real-world data and expertise improve design, speed recruitment, and advance cardiovascular, renal, and metabolic care.

 

Fragmented Source Data Is Costing Trials Time And Quality

Central eSource transforms the conduct of clinical trials by replacing disparate, site-specific source templates with a unified, sponsor-designed framework.

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