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Elutriation: How It Works

korus

Our counterflow centrifugation system operates on the principle of elutriation. Elutriation is a process for separating cells based on their size, shape and density. Discover the four stages in the lymphocyte elutriation process.

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What is elutriation?

The Korus™ counterflow centrifugation system operates on the principle of elutriation. Elutriation is a process for separating cells based on their size, shape and density using a stream of fluid flowing in the opposite direction to the centrifugal force.

The benefits of elutriation are:

  • Separation of target from non-target cells
  • Gentle production of a non-pelleting cell bed

Monocyte elutriation

Up to 88.6% monocyte purity and 75.0% recovery. Isolation of monocytes for downstream processes such as dendritic cell (DC) maturation.

Lymphocyte elutriation

Up to 85.2% lymphocyte recovery and 90.3% purity, providing a cleaner starting material for CAR-T or TIL manufacturing.

Cell wash

Maximizing cell recovery and contaminant removal.

Manufacturing processes

  1. Loading: Transfer of input cells into chamber(s).

  2. Transfer fraction: Transfer of lymphocytes from fraction bag to chamber for concentration.

  3. Elutriation: Increased counterflow removes smaller cells (lymphocytes) from chamber(s) to fraction bag.

  4. Harvest: Transfer of cells from chamber to harvest bag in a user-defined volume.

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