From Protocol To Patient: A New Blueprint For Transforming Feasibility And Recruitment

Despite decades of advancement in clinical research, one of the industry’s most stubborn challenges remains: the disconnect between protocol design and patient recruitment. Time and again, trials falter not because the underlying science is weak, but because execution proves impossible. Sponsors invest significant resources into developing protocols, only to learn — often too late — that their inclusion and exclusion criteria are overly restrictive, their enrollment forecasts overly optimistic, or their intended patient populations simply out of reach. The result? Costly amendments, delayed timelines, and under-enrolled studies.

This strategic playbook presents a new, integrated model for feasibility — one that bridges the long-standing gap between planning and delivery. By connecting Citeline’s Cohort SmartBuilder and Citeline PatientMatch, sponsors can harness the combined power of real-world data (RWD), proprietary Citeline intelligence, and AI-driven analytics in a single, seamless workflow. The outcome is transformative: protocols that are scientifically rigorous and operationally feasible — designed from the start for real-world success.