How Rescue Studies Use Direct-To-Patient Strategies To Accelerate Clinical Trial Enrollment

Even the most meticulously planned clinical trials can stall, often due to the high-stakes challenge of patient enrollment. When timelines slip and costs escalate, incremental fixes are rarely enough, and clinical trial rescue strategies become necessary. When traditional recruitment models hit a plateau, often because they rely heavily on finite site databases and local referral networks, a tech-enabled rescue strategy can shift the focus toward direct-to-patient engagement.

By utilizing global digital outreach combined with protocol-aligned online screening, sponsors can identify high-intent candidates far beyond the reach of traditional brick-and-mortar sites. Sophisticated clinical phone screening and EMR intelligence further refine this funnel, ensuring that sites receive "trial-ready" referrals. This approach reduces the administrative burden on study coordinators and accelerates the path to randomization. Beyond immediate recovery, these strategies foster a more resilient study framework by improving the patient experience through consistent communication and transparent next steps, ultimately protecting both the budget and the delivery of potential new therapies.