How To Reduce Screen Fail Rates

Recruiting eligible patients for clinical trials is crucial for advancing medical research, yet high screen fail rates—where interested candidates are deemed ineligible—pose significant challenges. Approximately 85% of clinical trials encounter recruitment-related issues, resulting in costly delays averaging $800,000 per day. In this full article, we explore the causes of screen fail rates, including poorly targeted outreach and ineffective screening processes, which disproportionately impact underrepresented demographics.

To mitigate these challenges, AutoCruitment proposes a multifaceted approach that leverages partnerships with patient recruitment vendors, enhanced digital marketing strategies, and refined online and phone screening tools. By segmenting patient audiences based on demographics and employing tailored communication strategies, trial organizers can attract qualified participants while minimizing unqualified applications. A case study of AutoCruitment demonstrates the effectiveness of these strategies, highlighting a 175% increase in enrollment for a Phase III Uterine Fibroid study. Ultimately, this research emphasizes that optimizing recruitment tactics not only reduces screen fail rates but also improves trial efficiency and outcomes, underscoring the importance of innovative approaches in clinical trial recruitment.