By Arturo Morales, Ph.D.
It’s not just pain. Clinical trials in pain are notoriously challenging and, too often, the problem isn’t the therapeutic being tested. Your drug may be efficacious, but your data didn’t prove it.
The problem is the data, and assay sensitivity--the ability to separate drug from placebo--is a frequent culprit. But this problem isn’t limited to pain or even CNS trials. Anywhere you have a subjective outcome you’re trying to make into an objective measure, you’ll encounter data problems. You may be able to identify them, but can you solve them?