Incorrect Clinical Trial Enrollment Is Preventable. A Tale Of Three Case Studies

By Catherine Tyner, Head of Clinical Strategy

Three clinical trials of increasing complexity demonstrate the consistent value of centralized eligibility review. Despite tighter eligibility windows, more subjective criteria, global operations, multilingual documentation, and imaging requirements, enrollment remained on track across all three studies. Using a centralized review process supported by an online workflow, study teams achieved high compliance with narrow eligibility timelines, completed reviews efficiently at scale, and eliminated enrollment-based protocol deviations. Most importantly, reviewers identified hundreds of patients who did not meet protocol requirements before enrollment.

These case studies show that centralized eligibility review is a scalable, quality-by-design solution that standardizes enrollment decisions, reduces eligibility risk, and delivers measurable ROI across therapeutic areas, trial sizes, and operational complexities.