Introducing 6M95C: A Novel Digital Measure For Tracking Disease Progression In Duchenne Muscular Dystrophy

Measuring disease progression in Duchenne muscular dystrophy (DMD) is a persistent challenge, particularly during the critical transition from ambulatory to non-ambulatory stages. While Stride Velocity 95th Centile (SV95C) is a qualified digital endpoint for walking patients, it loses utility once ambulation is lost. This creates a significant gap in assessing functional capacity as the disease advances.

A groundbreaking study in Pediatric Neurology introduces the Six-Minute Activity 95th Centile (6M95C), a novel digital measure designed to bridge this gap. This accelerometry-based tool provides a sensitive, real-world view of functional capacity across all disease stages, including non-ambulatory phases. By implementing continuous monitoring, researchers can unlock more objective insights into disease progression, ultimately accelerating the development of life-changing therapies for the DMD community.