ISPOR 2024-2025 Top 10 HEOR Trends

The 2024–2025 landscape of Health Economics and Outcomes Research (HEOR) reflects a pivotal transformation shaped by technological innovation, evolving health policies, and a deeper commitment to equity and patient-centric care. This report outlines ten defining HEOR trends influencing global health decision-making. At the forefront is the integration of artificial intelligence (AI), which is revolutionizing evidence generation and decision-making frameworks. Emphasis on real-world evidence continues to grow, driving regulatory and payer confidence. Digital health technologies are advancing patient monitoring and intervention personalization.

The global health equity movement is prompting methodologic innovation to address disparities in access and outcomes. Additionally, environmental sustainability is emerging as a core HEOR concern, linking health outcomes to planetary health. Market dynamics are shifting due to the proliferation of novel therapies and value-based contracts, especially in high-cost conditions like oncology and rare diseases. Regulatory harmonization efforts aim to streamline data use and methodological standards internationally. Collectively, these trends along with others signal HEOR's expanding role as a strategic cornerstone for achieving more effective, equitable, and sustainable health systems.