Key #4 For Successful ePRO Selection In Your Ophthalmology Clinical Trial: Consider The Method Of ePRO Administration

PROs in ophthalmology trials can either be self-administered by the patient or the responses can be collected through an interview, administered by the investigator or site personnel. They both present advantages and drawbacks that can affect the responses provided by the patients.

PROs for patients participating in ophthalmic trials may necessitate an interview mode because of potential visibility limitations. If the population skews more elderly, there may be additional dexterity limitations or technology difficulties. However, there are limitations with using an interview mode.

Selecting the method of questionnaire administration should take into consideration what the preferred method would be for the patient, to encourage the most accurate responses, and reduce potential biasing effects. This video highlights why this must happen early in the questionnaire selection process, as well as the implications in the research methodology and validity of the results of research.