6 Key Trials For Understanding Adaptive Designs For Clinical Trials

By Esha Senchaudhuri

Suppose you had to choose six clinical trials intended for registration with regulatory agencies, only six, to explain to young statisticians what the scope and promise of an adaptive or group sequential design truly is. Which trials, which methods and which strategies would you highlight? Would you choose to focus on the uncertainties related to placebo response or primary effect size? Would you highlight trials that shaved years off of a traditional design, while still revealing efficacy? Would you focus on the opportunities for population enrichment or dose selection? Would you take clinical development by the horns and explain the immense benefits of seamless trials?