Movement Disorder: Cardinal Symptoms Monitoring Solution
Cardinal Symptom Monitoring for Parkinson's and Huntington's Disease Trials
Continuous, objective tracking of cardinal symptoms in chronic diseases can support a better understanding of disease progression and treatment response.
In clinical trials for movement disorders such as Parkinson's disease and Huntington's disease, the primary motor endpoints typically rely on clinician-administered rating scales. However, a single clinic visit only captures a snapshot of a complex condition with cardinal motor symptoms that often fluctuate hour to hour.
In chronic and/or progressive disorders, symptoms can be highly variable from day-to-day and between individuals. Continuous, real-world data from low-burden wearable devices enables more objective and sensitive measures to adequately capture symptom fluctuations and progression over time. Ametris' wearable digital health technology platform gives researchers a powerful tool to capture clinically meaningful metrics with a single, fit-for-purpose wearable device.
Ametris' Movement Disorder Cardinal Symptom Monitoring solution enables continuous, passive monitoring of real-world abnormal movement behaviors to better characterize disease progression and therapeutic effect in Parkinson's disease and Huntington's disease research and drug development.
Ametris has partnered with PKG by empatica to deliver a suite of clinically validated algorithms for the measurement of abnormal movements in movement disorders, enabling the use of wearable devices for Parkinson's disease, Huntington's disease, and Essential Tremor research.
Fit-for-Purpose Wearable Solution: Movement Disorders
Our fit-for-purpose solution pairs the ActiGraph LEAP, a wrist-worn, multi-sensor wearable device, with a suite of clinically validated algorithms from PKG by Empatica to capture cardinal motor symptoms of Parkinson's disease and Huntington's disease in daily life and deliver a suite of clinical trial-ready digital measures.
Commonly Used Mobility Measures
- Bradykinesia Score
- Dyskinesia Score
- Percent Time Tremor
Clinical Trial-Ready Digital Measures
- Bradykinesia Score (BKS)
- Active Bradykinesia Score (Active BKS)
- Percent Time Bradykinesia (PTB)
- Dyskinesia Score (DKS)
- Percent Time Tremor (PTT)
- Fluctuations and Dyskinesia Score (FDS)
Get Started
To learn more about Ametris' fit-for-purpose Movement Disorder Cardinal Symptom Monitoring solution or discuss your specific study needs, please contact us to schedule a meeting with a member of our Science Team.