Overview Of Hepatitis B: Global Clinical Trials Landscape

Hepatitis B is a major global health challenge leading to severe liver complications, including cirrhosis and cancer. While current antiviral treatments effectively suppress viral replication and slow disease progression, they do not offer a functional cure. However, emerging therapies and ongoing clinical trials are paving the way for more advanced treatment strategies.

Research efforts are increasingly focused on achieving a functional cure by targeting HBV replication and enhancing immune control. Novel approaches include RNA-based therapies, monoclonal antibodies, and gene-editing technologies. Immunotherapy strategies, such as checkpoint inhibitors and therapeutic vaccines, are also being explored. Recent breakthroughs in precision medicine, including the identification of new biomarkers like HBV RNA and HBcrAg, are improving disease monitoring and personalized treatment approaches. As research advances, the prospect of a functional cure for Hepatitis B is becoming increasingly tangible, offering hope for millions worldwide.