Point Of Care: Cardiac Biomarker Tests

Source: Blinded Diagnostics
Point Of Care: Blood Gas Tests
Point of Care Cardiac Biomarker tests include Troponin I, CK-MB, BNP, Pro-BNP, D-Dimer and Myoglobin, with results in minutes.

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Point Of Care Solutions For Pharmaceutical Clinical Trials

Blinded Diagnostics specializes in the application of point-of-care diagnostic platforms for testing patients enrolled in clinical trials.

Point of Care Cardiac Biomarker tests include Troponin I, CK-MB, BNP, Pro-BNP, D-Dimer and Myoglobin. CLIA-Waived and moderately complex platforms use small blood volumes of whole or venous samples. Time to results in minutes. See an expanded list of POC tests at

Cardiac biomarkers are substances that are released into the blood when the heart is damaged or stressed. Measurement of these biomarkers are used to help diagnose, risk stratify, monitor and manage people with suspected acute coronary syndrome (ACS) and cardiac ischemia.

ACS and cardiac ischemia symptoms can vary greatly but frequently include:

  • Chest pain
  • Pressure, nausea
  • Shortness of breath
These symptoms are associated with heart attacks and angina, but they may also be seen with non-heart-related conditions.

Increases in one or more cardiac biomarkers can identify people with ACS or cardiac ischemia, allowing rapid and accurate diagnosis and appropriate treatment of their condition. ACS is caused by rupture of a plaque, which causes blood clot (thrombus) formation in coronary arteries resulting in a sudden decrease in the amount of blood and oxygen reaching the heart. Cardiac ischemia is caused when the supply of blood reaching heart tissue is not enough to meet the heart's needs.

The root causes of both ACS and cardiac ischemia are usually atherosclerosis and buildup of plaque, resulting in severe narrowing of the coronary arteries or a sudden blockage of blood flow through these arteries. Cardiac biomarker tests are ordered to help detect the presence of ACS and cardiac ischemia and to evaluate their severity as soon as possible so that appropriate therapy can be initiated.

It is important to distinguish heart attacks from angina, heart failure, or other conditions that may have similar signs and symptoms because the treatments and monitoring requirements are different.

For heart attacks, prompt medical intervention is crucial to minimize heart damage and future complications. Cardiac biomarker tests must be available to the doctor 24 hours a day, 7 days a week with a rapid turn-around-time. Some of the tests may be performed at the point of care (POC) – in the Emergency Room or at the person's bedside. Serial testing of one or more cardiac biomarkers is necessary to ensure that a rise in blood levels is not missed and to estimate the severity of a heart attack.

Angina is caused by a decrease in the supply of blood to the heart. When blood flow to the heart is blocked or significantly reduced for a longer period of time (usually for more than 30-60 minutes), it can cause heart cells to die and is called an acute myocardial infarction (AMI or heart attack). This leads to death of the affected portion of heart muscle with permanent damage and scarring of the heart and sometimes can cause sudden death to the person.

Only a few cardiac biomarker tests are routinely used by physicians. The current biomarker test of choice for detecting heart damage is troponin. Other cardiac biomarkers are less specific for the heart and may be elevated in skeletal muscle injury, liver disease, or kidney disease. Many other potential cardiac biomarkers are being researched, but their clinical utility has yet to be established.

See an expanded list of POC tests at

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Point Of Care Solutions For Pharmaceutical Clinical Trials