Reducing Variability With Independent Experts

Clinical trials that rely on complex ClinRO measures — particularly in CNS research — must contend with rater variability, inconsistent scale administration, and the risk of functional unblinding, all of which can erode endpoint reliability and threaten study success.

Signant’s Central Rating & Central Review services address these challenges by drawing on a global network of more than 800 rigorously trained, calibrated expert raters who deliver consistent, independent assessments supported by continuous quality oversight. This centralized model reduces variability at its source, strengthening signal detection and enhancing confidence in trial outcomes.

With flexible deployment models that adapt to the scientific and operational needs of each protocol, Signant offers fit-for-purpose central expert solutions that span the full spectrum of CNS and complex assessment requirements — helping sponsors safeguard data integrity from early screening through final evaluation.