Retention Begins With Recruiting The Right-Fit Patients

Recruiting patients for clinical trials is difficult on its own, but keeping them enrolled is often the greater challenge. Retention rates above 80% are widely considered essential to preserve data integrity and support the study’s primary endpoints, yet industry averages tell a different story: roughly one in five participants drops out before completion. Common drivers of attrition include side effects, logistical burdens such as travel and scheduling, limited support, and inadequate communication. These losses not only undermine statistical power but also delay timelines, increase costs, and risk the overall success of the study.

To reduce this preventable attrition, sponsors must take a proactive, two-part approach. It begins with recruiting the right-fit participants — those who meet clinical criteria and are realistically able to commit to the study’s demands. From there, sponsors should implement thoughtful retention strategies that prioritize patient comfort, accessibility, and engagement. Streamlined logistics, clear and continuous communication, personalized support, and flexible participation options can significantly strengthen patient commitment and ensure they remain confident, informed, and motivated throughout the trial.