Strengthening Psychiatric Eligibility In CNS Trials

By Juliet Brown, Ph.D. & Rachel Berman, Ph.D.

In CNS clinical trials, ensuring accurate psychiatric eligibility assessments is the key to reliable data, patient safety, and trial success. By introducing an objective, standardized approach to screening, Psychiatric Eligibility Reviews help sponsors reduce diagnostic errors, control for bias, and enhance overall study integrity. Expert clinicians assess comprehensive screening data to ensure only appropriate participants are enrolled, minimizing data noise and strengthening signal detection.

But that’s just the beginning. How do these reviews mitigate risk in high-complexity trials? What role do they play in preventing misdiagnosis and cognitive bias? And how can they be optimized with structured frameworks like the DSM-5-TR Differential Diagnosis Model? Discover how Independent Psychiatric Eligibility Reviews are transforming CNS clinical trials—and why integrating them into your study design could be the key to success.