The Silent Saboteurs: Why Rater Drift And Site Unpreparedness Cost CNS Trials More Than Technology Ever Could

Central nervous system (CNS) trials face some of the highest failure rates in clinical research, and technology alone isn’t the culprit. Evidence shows that inadequate site preparation, insufficient rater training, and caregiver burden undermine even the most advanced eCOA platforms. Rater drift — variability in administering and scoring neurological assessments — can erode data integrity by up to 72%, while poor logistics and lack of backup protocols lead to baseline data loss as high as 40%. These failures extend timelines, inflate costs, and compromise trial validity.

The resource highlights why prevention-focused strategies — comprehensive training, readiness assessments, and caregiver support — deliver better ROI than reactive technology fixes. Learn how to build resilience into CNS trial operations with evidence-based frameworks that prioritize human factors alongside digital tools. Download now to explore practical steps for reducing risk and improving data quality in complex neurological studies.