Expedited review is a type of IRB review of research carried out by the IRB chairperson or designee that is an experienced IRB member and reviewer rather than the convened IRB. It is important to remember that research is only eligible for expedited review when specific criteria are met. This paper is designed to provide practical guidance about when expedited review is an appropriate option for research. In the event expedited review is determined to be inappropriate for the research, it’s often a surprise and can cause frustration. Becoming familiar with the expedited requirements is a good way to ensure you can navigate the review process effectively.