Article | January 6, 2026

Top Clinical Trial Enrollment Challenges And How To Solve Them With Direct-To-Patient Recruitment

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Despite advancements in clinical research, approximately 85% of trials still fail to meet their enrollment or retention targets. Traditional site-based models often struggle with rigid eligibility criteria and limited geographic reach, which inadvertently creates a diversity gap. To address these challenges, a shift toward direct-to-patient (DtP) recruitment strategies is proving essential. By utilizing privacy-compliant digital targeting and HIPAA-compliant processes, sponsors can reach a broader, more representative participant pool beyond local clinic boundaries

These tech-enabled methods streamline the journey from initial awareness to randomization through plain-language education, transparency, user-friendly technology, and flexible patient screening options. Furthermore, integrating participant support—such as omnichannel engagement and hybrid trial options—drastically reduces dropout rates. Learn how AutoCruitment can help your study move toward these patient-centric, data-driven solutions, allowing sponsors to eliminate recruitment bottlenecks and ensure that life-saving therapies reach the market efficiently.

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