Article | March 4, 2026

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The forecast highlights five influential trends expected to drive health policy throughout 2026, focusing less on sweeping legislation and more on how existing priorities are interpreted and implemented. Administrative approaches to drug‑pricing reform will continue to evolve, with agreements, pilot models, and regulatory discretion playing central roles.

Rising affordability concerns—including premiums, cost sharing, and out‑of‑pocket expenses—are set to intensify pressure on policymakers and stakeholders to seek more sustainable solutions. As new pricing structures take effect, scrutiny around clinical benefit, transparency, and broader value assessments is anticipated to grow. Globally, investment patterns may shift as countries react to policy changes, influencing where future biomedical advances emerge and how they reach markets. Additionally, artificial intelligence is expected to become increasingly relevant in regulatory science and consumer experiences, shaping oversight, navigation, and trust in healthcare systems.

Together, these trends signal a year defined by implementation, evaluation, and strategic adaptation.

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ISPOR—The Professional Society for Health Economics and Outcomes Research