Article | April 28, 2025

What Is The Role Of Large Language Models In Real-World Evidence Generation?

By Aracelis Torres, PhD, MPH, SVP of Data & Science

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The integration of real-world data (RWD) with large language models (LLMs) is revolutionizing the healthcare landscape, facilitating the generation of real-world evidence (RWE) that enhances patient care and treatment personalization. Here we explore the potential of LLMs in processing RWD, including structured and unstructured electronic health record (EHR) data. This enables healthcare providers and life sciences companies to gain deeper insights into patient journeys.

By employing advanced natural language processing (NLP) and machine learning techniques, LLMs can extract critical information from free-text clinical notes, which complements traditional structured data analysis. These advancements underscore the necessity of high-quality RWD sources and the continuous refinement of AI algorithms to ensure accuracy and relevance. Ultimately, the synergy between LLMs and RWD holds the promise of delivering comprehensive insights into treatment outcomes and patient experiences, paving the way for enhanced disease management and improved healthcare decision-making.

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