Featured Articles
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The Model-Based Approach: A Better Way To Forecast Enrollment
2/17/2022
This white paper delves into one of the critical questions facing trial planners: "Can we recruit the required number of patients (e.g., 1000) within the assigned time (e.g., 25 months)?"
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Discover The Value Of An Optimized Clinical Data Strategy
2/17/2022
In this eBook, learn about the key elements of planning a clinical data strategy for the entire duration of a development program, specifically for Phase 1 and Phase 2 trials.
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Strategic Clinical Trial Design Unlocks Innovative Funding Opportunity
1/18/2022
A small biotech sponsor developing a new treatment for carcinoma asked for assistance with their trial design. Working with a constrained R&D budget, the challenge was to gather the evidence in a cost-effective manner and use a stage-gate approach for the funding. Explore the solutions uncovered in this case study.
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Optimizing Interim Analyses To Conserve Resources And Speed Strong Therapies To Market
1/18/2022
Gain insight into how providing sponsors with an efficient way to consider a large number of clinical trial design options can help ensure that effective drugs have the best opportunity to demonstrate their value and reach the market in a timely fashion.
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Single Arm Multi-Stage Phase 2 Cancer Trials: Reviewing Essential New Designs
1/11/2022
The rise of Bayesian methods has meant that predictive power can be used to assess efficacy during these single arm Phase 2 studies, but how do they differ from traditional designs and when should they be used?
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A Bayesian Optimal Design Advancing The Precision Medicine Approach
1/11/2022
This blog post describes how precision medicine allows physicians to identify individual patient characteristics or tumor types that might be most susceptible to a given therapy and represents a huge advance in cancer care.
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Optimal Promising Zone Designs: What Biotechs Need To Know
1/11/2022
Cyrus Mehta and Stuart Pocock’s Promising Zone Design for sample size re-estimation has been the subject of much debate and exploration. Explore how research has led to further questions about how to optimize such designs, and particularly how biotechs and pharmaceuticals might employ different strategies to achieve such optimization.
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Quantitative Bias Analysis To Strengthen Comparative Effectiveness
11/15/2021
As more payers and HTA agencies turn to real world data to compare the effectiveness of various treatment effects, learn how two sources of bias might become problematic for sponsors.
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Finding The Optimal Trial Design Using Operations Research Methods
10/5/2021
Trial designs are increasing in complexity and finding the optimal design from the millions of possible design options requires interactive blending of skilled judgement and statistical models.
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How To Ensure You Get Optimal Study Power For Your Investment In Time And Cost
10/5/2021
Cytel’s new position paper takes trial sponsors through a step-by-step process for how to obtain this full set of optimized clinical trial designs.