Featured Articles
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Novel Uses Of Scoring Functions In Clinical Trial Design Selection
10/1/2021
As the number of possible clinical trial designs have exponentially increased, the need to construct a new set of quantitative tools for accelerated comparison of these designs has become critical for trial selection. Read more to see how expansive simulation, Pareto optimization, and scoring functions work in tandem.
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Progression Free Survival Or Overall Survival? Reconciling An Old Debate With Modern Technology
10/1/2021
Building clinical trial designs that optimize across both progression free survival (PFS) and overall survival (OS) has historically proven challenging, but new technology has paved the way for new methods to find these potent designs.
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Three Underappreciated Benefits Of Pareto For Empowered Trial Selection
10/1/2021
This piece highlights some of the ways Pareto Optimization techniques can save decision-makers from expending time and energy on designs that do not deliver on their promise.
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Use Of Scoring Functions For Clinical Trial Optimization
8/26/2021
Cytel provides an overview of how Scoring Functions can be implemented for enhanced clinical trial selection.
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Mathematical Methods For Clinical Trial Financial Strategy
8/26/2021
When Cyrus Mehta introduced the Promising Zone Design over a decade ago, the new statistical method not only transformed the allocation of scarce resources within a clinical trial setting but also re-conceptualized how sponsors could increase investment in their trials. Read about the Promising Zone Design in this blog post.
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Use Of Rolling-Enrollment Designs To Accelerate Clinical Trials
8/16/2021
Cohort-based enrollment can thus slow down dose-finding trials since the outcomes of the previous cohort must be fully evaluated before the next cohort can be enrolled. This type of cohort-based designs can also be inefficient, especially if the trial needs to be frequently suspended. Read how to shorten the study duration of phase I trials and reduce the number of accrual suspensions with the use of rolling-enrollment designs.
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Thinking Of Clinical Development From A Bayesian Lens
8/16/2021
Learn where Bayesian methods should be injected into the process of optimization at the program and portfolio level of the clinical development journey.
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Utilizing Bayesian Analysis To Make Go/No-Go Decisions In A Platform Trial
6/29/2021
In recent years, platform clinical trials have gained substantial support and provide an efficient way of testing multiple compounds in a single and consistent framework. In this presentation we review platform trials including terminology, protocol structure overview and discuss some of the key advantages. We also share a concept for a platform trial that utilizes Bayesian modeling to make Go/No-Go decisions and discuss the potential benefits and risks of a platform trial.
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A Data-Infused Approach To De-Risking Clinical Trials
6/25/2021
For many decades the Pareto Frontier has been employed by actors in the private sector to evaluate and understand the benefits of various strategic options. When trying to understand the risks and benefits of a clinical strategy, Cytel researchers urge using a modified version of this process, built primarily with clinical development in mind. In this blog learn more about using the Pareto concept in clinical strategy and decision-making.
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Selecting A Clinical Trial Design: How Broadly Should You Explore?
6/25/2021
When selecting clinical trial designs, how many design options should a sponsor explore? Would a sponsor feel more confident having an optimized design out of ten potential ones, or simulating several million designs to discover that there are three or four better options? Cytel’s experience suggests that this depends very much on the specific sponsor and the specific conditions of the clinical trial. Here are five considerations for sponsors when making this complex decision.