Precision For Medicine Case Studies

1. Developing And Validating Clinical Receptor Occupancy Pharmacodynamic Biomarker Assays 9/25/2025

   Receptor occupancy (RO) assays assess drug-target engagement and support PK/PD modeling. Accurate RO requires customized assays using stabilized blood to monitor CD6 modulation in autoimmune therapy.

2. Rapid Startup Phase 1 Cardiomyopathy CRISPR Gene Therapy 9/25/2025

   Hereditary transthyretin amyloidosis (ATTRv) is very rare, prompting a Phase 1 trial of in vivo CRISPR/Cas9 gene editing to reduce mutant protein and stop cardiomyopathy progression.

3. Use Of Epiontis ID In A Phase 2 Psoriasis Trial 9/25/2025

   Mirikizumab’s Phase 2 trial explores IL-23 inhibition in psoriasis, measuring immune cell changes to assess its potential for long-term disease control and flare-up prevention.

4. Optimizing Kitting For Cell Therapy Trials In Pediatric Oncology 5/2/2025

   Precision for Medicine’s Kitting team played a crucial role in overcoming this challenges of a Phase I multicenter pediatric cell therapy trial targeting relapsed or refractory solid tumors.