Newsletter | April 15, 2026

04.15.26 -- Best Practices In Designing An Adaptive, Open-Label RCT Phase 3 Oncology Trial

SPONSOR

Smart Sourcing: Patient Recruitment & Retention Showcase, a virtual event for clinical teams to explore and compare top patient recruitment and engagement partners. Expect live, side-by-side comparisons, real-time Q&A, and practical insights to boost enrollment, diversity, and retention. Ideal for Clinical Ops, Site Engagement, and Vendor Management teams. Leave with a vetted shortlist of partners and actionable takeaways—without the time, cost, or travel of traditional conferences.

TRIAL MANAGEMENT

Adapt Or Die: Best Practices In Designing An Adaptive, Open-Label RCT Phase 3 Oncology Trial

Guest Column | By Lew Bender, Intensity Therapeutics

Discover how adaptive trial design can deliver greater operational efficiency, improved efficacy outcomes, and enhanced sponsor affordability across the drug development life cycle.

Unique IRT Implementation Considerations For Personalized Medicine

White Paper | Almac Clinical Technologies

The rise of personalized and precision medicine is reshaping the clinical trial landscape and, as the number of these specialized trials increases, so does the complexity of managing them effectively.

Modernizing Clinical Trial Logistics To Deliver Value

White Paper | Thermo Fisher Scientific

Explore how biopharma organizations can design and operate clinical supply systems that absorb complexity while maintaining control and consistency.

Transforming PAH Trials For Patient-Centric Care

Article | By Nicole Zandy and Scott Oakes, IQVIA Biotech

PAH trials need patient-focused strategies. See how innovative designs, digital tools, and real-world data can simplify recruitment, reduce complexity, and improve outcomes in this challenging space.

The Case For Parallel Processing In Clinical Trial Start-Up

Article | By Kimberly Ponder, Avacare

Stop letting outdated processes stall your innovation and learn how parallel processing transforms study start-up from a series of hurdles into a synchronized sprint.

How Integrated Early Development Is Rewriting Proof-of-Concept

Article | By Matt Paterson, Biorasi

How can you move faster from First-in-Human to Proof-of-Concept? Learn how integrating real-time manufacturing and clinical data removes the gaps that stall early development programs.

RTSM Solutions That Adapt To Your Needs

Product | Endpoint Clinical

With our flexible RTSM technology, you can manage trials throughout their full cycles.

Transforming the Path To Life‑Changing Patient Therapies

Brochure | PA Consulting

Accelerate your therapy's path to market and create better experiences with the right partner to provide end-to-end Clinical Development expertise.

SPONSOR

As outsourcing expands, clinical trial success increasingly depends on stronger sponsor-CRO alignment. This webinar explores the growing disconnect between sponsors, CROs, CRAs, and sites, and how fragmented operations can impact execution. Hear practical strategies to improve oversight, strengthen collaboration, reduce risk, and build more cohesive, site-friendly, high-performing clinical trial operations from start to finish. Click here to learn more.

DECENTRALIZED TRIALS

RFK Jr. Wants Every American Wearing A Wearable. How Can Pharma Build A Business Around It?

Guest Column | By Smit Patel, Digital Medicine Society (DiMe)

The timing is now for pharma to be all-in on using wearables as their new business strategy, says Digital Medicine Society (DiMe) Director of Partnerships Smit Patel, PharmD.

CHOOSE YOUR OWN ADVENTURE

You're receiving the Wednesday edition of the Clinical Leader newsletter, focusing on Decentralized Trials and Trial Management. To make changes to your newsletter selections, update your topic preferences.

  • Clinical Sites | Patient Centricity | Patient Recruitment (Monday)
  • Clinical Trial Technology (Tuesday)
  • Decentralized Trials | Trial Management (Wednesday)
  • Outsourcing Models | Regulatory & Compliance (Thursday)
  • Clinical Data Management & Analytics | Trial Monitoring (Friday)

Learn more about our personalized newsletters here.

Connect With Clinical Leader: