Developing Community-Based & Trial-Naïve Sites: The Real ROI

The clinical trial ecosystem is facing increasing pressure to expand access to diverse patient populations, yet traditional reliance on large academic medical centers often creates barriers that limit participation. Patients in community settings may struggle with travel, financial, or logistical challenges, which in turn restricts enrollment and diversity. At the same time, sponsors and clinical research organizations are seeking ways to accelerate recruitment, reduce site competition, and extend the reach of their studies beyond overburdened hubs.

Trial-naïve sites—such as community hospitals, regional clinics, and smaller healthcare providers—are emerging as a vital solution. Though these sites often require significant investment in training, infrastructure, and regulatory support, they offer access to previously untapped patient groups, faster enrollment potential, and the ability to strengthen long-term research networks. When supported effectively, trial-naïve sites can transition quickly into capable contributors, delivering operational efficiency and improved retention while reducing dependence on high-volume centers.