Overcoming Barriers To Clinical Trial Participation In Oncology: The Value Of Home Trial Support & Site Networks

Recruiting and retaining patients for oncology clinical trials is complex, with multiple barriers impacting participation. Many trials fail to meet enrollment targets due to issues like limited awareness, misconceptions about trials, and logistical challenges. Patients often face difficulties such as travel constraints, financial limitations, and restrictive eligibility criteria. These obstacles are compounded in community-based settings, where limited infrastructure and resource constraints further hinder participation. Despite patients' willingness to enroll, a significant disparity exists between trial participation rates at major academic centers and community sites.

The COVID-19 pandemic exacerbated these challenges but also catalyzed a shift toward decentralized clinical trials (DCTs). These designs enable patients to participate in trials from their homes or local sites, reducing logistical and emotional burdens. Home Trial Support services, which provide in-home visits by healthcare professionals, have been particularly effective in improving access and retention for oncology patients. These approaches democratize trial access, especially for rural and underserved populations, by addressing barriers like extensive travel and limited mobility.

Expanding site networks to include community facilities, coupled with adequate training, resources, and centralized platforms, can improve recruitment and retention. By integrating patient-centered solutions and decentralized models, oncology trials can become more inclusive, reach diverse populations, and accelerate the development of life-saving therapies.