Protocol Design White Papers & Case Studies

1. Decentralized Trials Support: Direct-To-Patient Supply Management 8/25/2025

   Direct-to-patient shipments are reshaping decentralized trials by placing patient convenience at the center of study design.

2. Master Protocols: Implementing Effective Treatment Adaptations 8/25/2025

   From balancing treatment ratios and managing subgroup eligibility to accommodating site-specific readiness and protocol amendments, a flexible, well-designed IRT system enables seamless transitions with minimal disruption.

3. Unique IRT Implementation Considerations For Personalized Medicine Trials 8/22/2025

   The rise of personalized and precision medicine is reshaping the clinical trial landscape and, as the number of these specialized trials increases, so does the complexity of managing them effectively.

4. Advancing Dose Escalation Strategies With Bayesian Modeling 8/12/2025

   A CRO was engaged to help a biotechnology sponsor develop a novel oncology therapy design and execute a multicenter, open-label Phase 1/2 dose escalation and expansion study in advanced solid tumors.

5. Recruiting High-Performing Sites To Beat Forecasted Trial Start Date 7/10/2025

   Explore a partnership that enabled Syneos Health to achieve its enrollment goals, increasing the likelihood of the study's success, and resulting in cost savings and maximized efficiency with minimal delays.

6. RWD, New Technologies Show Potential In Clinical Trial Recruitment 7/10/2025

   Leveraging RWD transforms feasibility and recruitment from reactive processes into strategic drivers of clinical trial success.

7. Fortrea Optimizes Site Matching On Retina Clinical Trials 6/27/2025

   Faced with challenges in engaging clinical trial sites within the retina research landscape, Fortrea sought a partnership that leverages RWD to streamline site feasibility assessments.

8. Rapid Results In A High-Stakes Dry Eye Disease Trial 6/26/2025

   This time-sensitive Phase 3 trial in dry eye disease required precision project management leveraging strong site relationships, ophthalmology-specific expertise, and data-driven site selection.

9. Powering Urologic Research With Exclusive Real-World Data 6/25/2025

   These high-quality, fit-for-purpose data modules are tailored to conditions such as prostate cancer, benign prostatic hyperplasia (BPH), non-muscle invasive bladder cancer (NMIBC), and more.

10. Disclosure Management System: Build Or Buy? 6/19/2025

    Clinical trial disclosure regulations are tightening worldwide. In order to maintain compliance, sponsors must determine whether to build an internal disclosure management system or buy a solution.