Preclinical applications and studies

  1. Advancing Immunotherapy In Head And Neck Cancer: The IT-MATTERS Study 4/17/2025

    This randomized controlled pivotal phase 3 study evaluated efficacy and safety of neoadjuvant complex biologic administered for 3 consecutive weeks pre-surgery.

  2. LC-MS/MS Method Development Of Endogenous Small Molecule Biomarker 1/17/2025

    Biomarkers are essential to improve drug R&D efficiency. Explore some practical solutions for achieving a fit-for-purpose LC-MS/MS biomarker analysis method.

  3. Drug Development Program Management 10/28/2024

    Learn how a consultant helped a biotech company specializing in immuno-oncology to develop timeline reports for the product and portfolio and identify and address gaps in the filing plan.

  4. A Versatile Application For Rapid Mass Confirmation And Purity Assessment Of Biotherapeutics 7/18/2022

    We explore a streamlined integrated workflow for data acquisition, processing and reporting of deconvoluted mass data for biotherapeutics, deployable in regulated and non-regulated environments.

  5. Transferring N-Glycan HILIC Separations Between UPLC And HPLC 7/18/2022

    We demonstrate that comparable chromatographic profiles and relative quantitation can be achieved with the larger particle size column at HPLC-compatible pressures, albeit with an increase in sample load, mobile phase use, and most importantly, analysis time.

  6. Improving Released N-glycan Analysis In Biotherapeutic Development Using Premier Solution With HPS Technology 7/12/2022

    Explore how we improved releasing N-glycan analysis in biotherapeutic development, which can help develop robust and unbiased glycan assays for biotherapeutic development, manufacture, and release.

  7. Method Migration Of Size-Exclusion And Ion- Exchange Methods For Monoclonal Antibody Analysis 7/12/2022

    Discover how combining this system with modern UHPLC columns could make data more accurately interpreted through greater efficiency, selectivity, and enhanced resolution.

  8. Rapid Size Variant Analysis of Monoclonal Antibodies Using SEC Columns 7/9/2022

    This study examines technological advancements in both the column hardware and packed particle chemistry of solution that provides extended column lifetimes when using physiological pH mobile phases.

  9. ACQUITY And XBridge Premier Protein SEC 250 Å Columns: A New Benchmark In Inert SEC Column Design 7/5/2022

    We demonstrate the performance of a new column technology designed to provide a holistic solution to the problems of undesired secondary interactions in SEC.

  10. Performance Stability Of CORTECS 2.7 μm Columns Following Repeated Injections Of Precipitated Plasma 7/1/2022

    We review a column made using optimally packed solid-core particles. These columns are designed to tolerate repeated injections of minimally processed samples, while maintaining assay performance.