Preclinical applications and studies

  1. Improvements In Recovery, Reproducibility, And Matrix Effects With A Novel Solid Phase Extraction Sorbent 6/30/2022

    In this study we review a successful next generation reversed  solid-phase extraction (SPE) product that produces cleaner extracts with simpler protocols and faster processing time.

  2. Selecting A Reversed-Phase Column For The Peptide Mapping Analysis Of A Biotherapeutic Protein 6/30/2022

    In this study we review reversed-phase (RP) column selection considerations for peptide mapping applied to the routine characterization and analysis of biotherapeutic proteins.

  3. BEH C18 Batch-To-Batch Robustness For The Analysis Of Rosuvastatin And Impurities 6/30/2022

    The main goal of this study is to investigate the long-term batch-to-batch reproducibility of 10 different lots of XBridge BEH C18 Columns. Discover the findings of this study.

  4. A Look At Column Reproducibility: Analysis Of Endogenous Steroid Hormones In Serum 6/30/2022

    Having reproducible columns is critical for the success of batch to batch testing of stationary phases, as well as ensuring lifelong performance for the assay.

  5. Increasing Chromatographic Performance Of Acidic Peptides In RPLC-MS-based Assays 6/30/2022

    We demonstrate how to increase productivity in the lab and mitigate risk through increased reproducibility, recovery, and robustness of assays performed in the development and manufacturing of biopharmaceutical drug products.

  6. Examining Column Reproducibility During Method Development In Clinical Labs 6/28/2022

    In this study demonstrates how the HSS T3 stationary phase is a reliable stationary phase, as three batches made over a five-year span provide comparable results.

  7. Engineering A PMA Study For A First-Of-Its-Kind Oncology Dx 3/8/2022

    A client developed a unique solution for Colorectal cancer screening – a multi-target, noninvasive screening test that could be facilitated by patients in their homes. Gather information on how the pre-market approval (PMA) study was conducted.

  8. Visual Analytics And Discovery Platform For Scientific And Clinical R&D 8/18/2021

    A pharmaceutical company was looking to deploy a software solution for a small R&D group. See how an enterprise-class visualization and analytics platform enabled maximized understanding of research data.

  9. Overcoming Clinical Challenges In Metabolic And Cardiovascular Disease With Metabolomics 4/10/2013

    Metabolic diseases (e.g. obesity, type 2 diabetes, and hypertension) are a rapidly expanding health care concern. Although there is a high demand for novel therapies, the challenges are substantial as existing drugs typically fail due to lack of efficacy or safety, and clinical studies often extremely large and protracted. 

  10. Overcoming Clinical Challenges In Oncology With Metabolomics 4/10/2013

    Cancer continues to be a formidable disease with an overall success rate of bringing new drugs to market of only 5-8%.