Site Management/Investigator Payments Featured Articles

1. The Promise Of Bispecifics In The Quest For Outpatient Immunotherapy 7/15/2026

   START San Antonio's Drew Rasco, MD, reflects on the evolution of immunotherapy and highlights how novel therapies such as bispecifics are both challenging and intriguing for principal investigators (PIs).

2. The Profit Margin Double Standard That Needs To Change 7/10/2026

   We expect pharmaceutical companies to have sizable profit margins, but we collectively scoff at research sites for achieving the same. Maria P. Ladd explores this difference in expectations and why it needs to change for the sake of the industry.

3. Why The Governed Hybrid Site Model Is Strategically Superior — Part 3 7/10/2026

   In the third and final part of this series, Paradigm Clinical Research CEO Kurt Mussina, who's become an advocate for the governed hybrid platform, explains why he believes it's the best fit for sponsors.

4. How Clinical Research Site Operating Models Perform in Practice – Part 2 7/9/2026

   In part two of this three-part series, Paradigm Clinical Research CEO Kurt Mussina evaluates how each site operating model performs regarding speed, patient access, investigator engagement, quality, accountability, and scalability.

5. Why Operating Model Is The Next Competitive Frontier In Clinical Research Site Strategy – Part 1 7/8/2026

   In this three-part series, Paradigm Clinical Research CEO Kurt Mussina discusses the meaningfulness of a site's operating model to clinical trial sponsors. In part one, he first defines operating model types.

6. What Sponsors Don't See: The Systems Behind Clinical Trial Delivery 6/22/2026

   What do sponsors need from sites? Easy. How do they evaluate them? Not so easy (or accurate). In this column, Association Multisite Research Corporations (AMRC) Executive Director Jim Kremidas explains how sites and sponsors can make site evaluations better.

7. What Really Happens At The Site When Sponsors Pull Back Mid-Trial 6/19/2026

   When sponsors slow or reduce operational spending due to financial pressure, strategic pivots, or internal restructuring, sites — and patients — suffer. Curo Research CCO Amy Bland explains how sponsors can better manage operational changes.

8. What's Wrong With Site Benchmarking? A Site-Centered Perspective On Its Alignment, Transparency, And Use 6/9/2026

   Benchmarking is widely used and highly valued, yet trust in it is limited. The League Benchmarking Working Group has set out to standardize how site metrics are defined, contextualized, and applied.

9. Can Independent Pharmacies Succeed Where Walgreens Failed? 5/21/2026

   Josh Rose, CEO of Hawthorne Health, believes independent community pharmacies may succeed where large retail chains struggled in clinical research. In this interview, Rose explains how Hawthorne is building pharmacy-based trial sites focused on underserved communities, chronic disease studies, and trusted patient relationships.

10. How Did You End Up In Clinical Research? 5/20/2026

    To commemorate Clinical Trials Day, we asked clinical researchers to share their story, answering, "How did you get into clinical research?"